现代食品科技2017，Vol.33Issue(7)：31-35,5.DOI:10.13982/j.mfst.1673-9078.2017.7.005
九香虫对慢性锰中毒大鼠生殖损伤的保护作用
Protective Effect of Aspongopus chinensis on Reproductive Injury Caused by Chronic Manganese Exposure in Male Rats
摘要
Abstract
Aspongopus chinensis was used for the intervention of damages caused by chronic manganese exposure to the reproductive system of male Sprague Dawley (SD) rats,and its mechanism of action was explored.The results showed that compared with the model group,the mating ability defined by the numbers of penile insertion,in the low-,medium-,and high-dose Aspongopus chinensis intervention groups was boosted by 2.65,2.62,and 1.65 times,respectively.The corresponding ejaculation frequencies were increased by 2.01,1.94,and 1.25 times,respectively,and the corresponding levels of serum testosterone were increased by 1.14,1.22,and 1.23 times,respectively.The results suggested that Aspongopus chinensis could repair damages caused by chronic manganese poisoning to the reproductive function of rats.Meanwhile,the morphological structures of the testicular tissue of the Aspongopus chinensis intervention groups were obviously improved when compared with those of the model group.However,there was no significant improvement in the organ coefficient of the testis and epididymis,the sperm count,as well as other aspects of reproductive ability.Furthermore,compared with the model group,the total superoxide dismutase (T-SOD) activity of the low-,medium-,and high-dose Aspongopus chinensis intervention groups was increased by 1.23,1.54,and 1.60 times,respectively,and the corresponding total antioxidant capacities (T-AOCs) were increased by 1.28,1.54,and 1.39 times,respectively.The results suggested that the protective effect ofAspongopus chinensis on reproductive injury in male SD rats was related to its antioxidant activity.This study provides a basis for the development of drugs to treat reproductive injury.关键词
九香虫/锰暴露/生殖损伤/生殖保护/氧化应激Key words
Aspongopus chinensis/manganese exposure/reproductive injury/protective effect on the reproductive system/oxidative stress引用本文复制引用
王凤月,刘川燕,付惠惠,王涌,王乾兴,侯晓晖..九香虫对慢性锰中毒大鼠生殖损伤的保护作用[J].现代食品科技,2017,33(7):31-35,5.基金项目
贵州省教育厅“125计划”重大科技专项(黔教合重大专项字[2014]031) （黔教合重大专项字[2014]031）
遵义市科技创新人才团队培养项目(遵市科合[2015]40号) （遵市科合[2015]40号）
贵州省中药现代化科技产业研究开发项目(黔科合中药字[2012]5001-1号) （黔科合中药字[2012]5001-1号）
贵州省“西部之光”项目 （）
遵义医学院博士启动基金项目([2013] 69) （[2013] 69）
