食品科学2017，Vol.38Issue(13)：160-166,7.DOI:10.7506/spkx1002-6630-201713027
枸杞多糖作用于2型糖尿病大鼠的血清代谢组学研究
Serum Metabonomics Study of Type 2 Diabetic Rats Administrated with Lycium barbarum Polysaccharides
摘要
Abstract
Gas chromatography-time of flight-mass spectrometry (GC-TOF-MS) was employed for serum metabolite profiling of rats in the control group (NC),type 2 diabetic model group (DM) and Lycium barbarum polysaccharides (LBP group) treatment groups.Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were used for clustering serum metabolite profiles and finding potential biomarkers.The results demonstrated that the three groups were successfully separated and serum alanine and thymidine were decreased in the DM group as compared to the NC group.One-month intervention with LBP could increase the levels of alanine and thymidine in serum of type 2 diabetic rats,which may be associated with their amino acid and nucleotide metabolism.These results can provide a reference for further study of the hypoglycemic mechanism of LBP.关键词
枸杞多糖/2型糖尿病/代谢组学/生物标志物Key words
Lycium barbarum polysaccharides/type 2 diabetes mellitus/metabonomics/biomarker分类
轻工纺织引用本文复制引用
唐华丽,夏惠,王锋,孙桂菊..枸杞多糖作用于2型糖尿病大鼠的血清代谢组学研究[J].食品科学,2017,38(13):160-166,7.基金项目
国家自然科学基金面上项目(81273069) （81273069）
江苏省普通高校研究生科研创新计划资助项目(KYLX_0205) （KYLX_0205）
重庆市基础与前沿研究计划项目(cstc2016jcyjA0522) （cstc2016jcyjA0522）
重庆市教委项目(KJ1601008) （KJ1601008）
