食品科学2017，Vol.38Issue(13)：196-200,5.DOI:10.7506/spkx1002-6630-201713032
紫山药多糖对D-半乳糖衰老模型大鼠肝、脑的影响
Effect of Purple Yam Polysaccharide on the Liver and Brain of D-Galactose Induced Aging Rats
摘要
Abstract
Objective:To study the anti-aging effect and mechanism of purple yam polysaccharide (PYP) on D-galactose induced aging model rats.Methods:The aging rat model was established by D-galactose injection for 45 days and administered simultaneously with PYP at 20,100 and 500 mg/(kg·d),and total antioxidant capacity (T-AOC),glutathione peroxidase (GSH-Px) activities and glutathione (GSH) and malondialdehyde (MDA) contents in brain and liver tissues were detected after the administration.The expression of p53 and p21 protein was evaluated using Western blot.Results:PYP at 100 mg/(kg·d) could improve T-AOC,GSH-Px and GSH contents in liver and brain tissues of D-galactose induced aging rats,decrease the production of MDA,and down-regulate the expression of p53 and p21 protein.Conclusion:Purple yam polysaccharide has a significant effect on defending against liver and brain aging in rats via a mechanism related to p53/p21 signaling pathways.关键词
紫山药多糖/衰老/p53蛋白/p21蛋白Key words
purple yam polysaccharide/aging/p53 protein/p21 protein分类
轻工纺织引用本文复制引用
张丽梅,程永强,宋曙辉..紫山药多糖对D-半乳糖衰老模型大鼠肝、脑的影响[J].食品科学,2017,38(13):196-200,5.基金项目
北京市农林科学院科技创新能力建设专项(KJCX20140111 （）
KJCX20150201) （）
