食品工业科技2017，Vol.38Issue(11)：344-347,4.DOI:10.13386/j.issn1002-0306.2017.11.058
黄秋葵水提物对2型糖尿病大鼠血尿酸及肾功能的影响
Effects of okra extract on serum uric acid and renal function in type 2 diabetes mellitus rats
宋春蕾 1何伟 1张灵敏 2李海霞 1窦伟峰 1王玲1
作者信息
- 1. 郑州大学公共卫生学院营养与食品卫生教研室,河南郑州450001
- 2. 中牟县卫生防疫站,河南中牟451450
- 折叠
摘要
Abstract
Objective:To investigate the effects of okra extract on serum uric acid and renal function in type 2 diabetes mellitus (T2DM) rats.Methods:72 male Sprague-Dawley (SD) rats were randomly divided into normal control group(8 rats) and T2DM model group (64 rats),fed with lab chow diet and high-sugar and high-fat diet respectively for four weeks.Then the rats in T2DM model group were injected with streptozocin (STZ)intraperitoneally to establish T2DM animal model.The successful model rats were further assigned into T2DM model,positive control(Jiang-tangning gavage,0.64 g/kg· d-1),low,medium and high dose of okra extract groups(okra extract at the dosages of 0.78,1.56 g and 2.60 g per kilograms of body weight was added into the high-sugar and high-fat diet taken by the rats).Administered four weeks,the urine samples were collected and the kidneys of the rats were dissected for evaluating the kidney index.Serum uric acid (SUA),serum creatinine(SCr) and blood urea nitrogen (BUN) were measured.Results:Compared with diabetic model group,the level of SUA in high dosage of okra extract group was significantly decreased (p ＜ 0.05),but the significant difference was not found in serum SCr and BUN between okra extract intervention groups (p ＞ 0.05).Conclusion:Okra extract may mitigate the level of SUA at a appropriate dosage in T2DM rats,the protective effect on renal function needs to be explored in the further researches.关键词
黄秋葵水提物/2型糖尿病/SD大鼠/血尿酸/肾脏Key words
okra extract/T2DM/SD rats/serum ucic acid/kidney分类
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宋春蕾,何伟,张灵敏,李海霞,窦伟峰,王玲..黄秋葵水提物对2型糖尿病大鼠血尿酸及肾功能的影响[J].食品工业科技,2017,38(11):344-347,4.
