中国食品学报2017，Vol.17Issue(6)：53-59,7.DOI:10.16429/j.1009-7848.2017.06.007
魔芋低聚糖对结肠炎大鼠肠道菌群的影响
Effect of Konja Coligosaccharide on Gut Microbiota in Rats with Ulcerative Colitis
摘要
Abstract
Objective:To explore effect of konja coligosaccharide (KOS) on gut microbiota in Rats with Ulcerative colitis and to explore possible mechanisms involved.Methods:Experimental rat colitis was induced by trinitrobenzenesulfonic acid (TNBS) and randomly distributed into four groups as follows:normal control group,model control group,KOS low dose group and high dose group.Assessment of colitis severity was performed daily.All rats were killed on the 14st day and their colon contents were dissected and collected:spread plate method was used to detect the content of feces Escherichia coli,Enterococcus,Bifidobacterium and Lactobacillus.Gas chromatography to determinate the types and contents of short-chain fatty acids.Results:Compared with the model group,KOS low and high dose group reduced the disease activity index score,improved the structure and function of gut microbiota:the Escherichia coli and Enterococcus decreased significantly,the Bifidobacterium and Lactobacillus have great proliferation and short-chain fatty acids increased significantly.Conclusion:The mechanism of KOS in relieving inflammation in colitis may be achieved by improving the structure and function of gut microbiota.关键词
魔芋低聚糖/溃疡性结肠炎/肠道菌群/短链脂肪酸Key words
konja coligosaccharide/Ulcerative colitis/gut microbiota/short-chain fatty acids引用本文复制引用
刘瑞雪,李勇超,张波..魔芋低聚糖对结肠炎大鼠肠道菌群的影响[J].中国食品学报,2017,17(6):53-59,7.基金项目
“十二五”国家科技支撑计划课题(2012BAD33B06) （2012BAD33B06）
