现代食品科技2017，Vol.33Issue(8)：18-23,50,7.DOI:10.13982/j.mfst.1673-9078.2017.8.004
植物组方提取物M的抗炎功效研究
Anti-inflammatory Activity of Extract M of Plant Combinations in SD Rats
摘要
Abstract
Sprague-Dawley (SD) rats were used as the experimental model in this paper whereby an SD rat model of inflammation was established by implanting cotton ball.Further,the effects of extract M of plant combinations on the body weight,food intake,and water intake of rats with cotton-ball-induced inflammation were studied.Enzyme-linked immunosorbent assay (ELISA) was employed to study the effects of extract M of plant combinations on the secretion of inflammatory mediators and synthetic pathways ofprostaglandin E2 and leukotriene in rats with cotton-ball-induced inflammation.The results showed that extract M had no significant effects on the body weight,food intake,and water intake of normal SD rats,however had a certain impact on the food intake of rats after the model of inflammation was established.Extract M could significantly alleviate the excessive secretions of C-reactive protein,nitric oxide,arachidonate 5-1ipoxygenase,and leukotriene C4 in the inflammation reaction,and had no significant inhibitory effects on the secretions of interleukin-lβ,tumor necrosis factor-α,prostaglandin E2,and cyclooxygenase 2.The above findings indicated that extract M of plant combinations exerted anti-inflammatory effects by inhibiting the synthesis of leukotriene C4 by arachidonate 5-1ipoxygenase and therefore can contribute to anti-inflammatory applications.关键词
肉芽肿/炎症/白三烯/前列腺素Key words
granulomas/inflammation/leukotriene/prostaglandin引用本文复制引用
高擎,任颖朗,葛亚中,游丽君..植物组方提取物M的抗炎功效研究[J].现代食品科技,2017,33(8):18-23,50,7.基金项目
广东省自然科学基金项目(2014A030313242) （2014A030313242）
中央高校科研业务费项目(2015ZZ110) （2015ZZ110）
