食品与发酵工业2017，Vol.43Issue(8)：169-176,8.DOI:10.13995/j.cnki.11-1802/ts.013503
川陈皮素纳米结构脂质载体的制备及稳定性评价
Preparation and stability evaluation for nobiletin nanostructured lipid carriers
摘要
Abstract
Nanostructured Lipid Carriers (NLC) are a new lipid nanoparticle system and are wildly used in many fields of food science and process.Nobiletin,a citrus polymethoxylated flavone is extracted from citrus fruit peels,and has many health benefits.Nanostructured NLC can increase its water-solubility and bioavailability.High pressure homogenization was used to prepare nobiletin nanostructured lipid carrier (NOB-NLC).Single factor design was chosen to study the influence of the amount of lipid,emulsifier and emulsifier ratio on the quality of NOB-NLC.Response surface design was used to optimize the preparation parameters.The optimal condition was:752.20 mg lipid,1072.41 mg emulsifier and 1.23 drug-lipid ratio.NLC-NOB exhibited spherical shape with diameter of (132.63± 7.28)nm,polydispersity index (0.253 ± 0.015),zeta potential (-38.1 ± 2.17) mV and an entrapment efficiency (80.25 ± 3.66) ％.The scanning electron microscope showed that the NOB-NLC were spherical shape.The influence of storage conditions on the stability of NOB-NLC was studied.The results indicated that NOB-NLC was stable after storage in dark at 25 ℃,pH 3.5-7.5 for 40 d,and the particle size is relatively consistent.It is available to the food systems with pH range of 3.50-7.50.关键词
纳米结构脂质载体/川陈皮素/Box-Behnken试验/表征/稳定性Key words
nanostructured lipid carriers/nobiletin/Box-Behnken design/characterization/stability引用本文复制引用
黄威,黄学根,窦华亭,吴厚玖,王华,孙志高,马亚琴,黄林华,郭莉,王珺..川陈皮素纳米结构脂质载体的制备及稳定性评价[J].食品与发酵工业,2017,43(8):169-176,8.基金项目
公益性行业(农业)科研专项(201303076-07) （农业）
重庆市2016年基础科学与前沿技术研究一般项目(cstc2016jcyjA-0552) （cstc2016jcyjA-0552）
