摘要
Abstract
An isotope internal standard coupled with gas chromatography-mass spectrometry (GC-MS) method was established for the simultaneous determination of four chloropropanol esters (3-chloro-1,2-propanediol, 2-chloro-1,3-propanediol, 1,3-dichloro-2-propanediol and 2,3-dichloro-2-propanol ester) in infant formula milk powder. Samples were dissolved and extracted withn-hexane, and then the extract was hydrolyzed by sodium methoxide in methanol, purified on a Florisil solid phase extraction column, derivatized with heptafluorobutyryl imidazole, detected by GC-MS in the single ion monitoring mode, and quantified by the internal standard method. Under the optimized conditions, all four chloropropanol esters showed good linearity in the range of 0.05–1.00 mg/L withR2 larger than 0.997. The detection limit of the method was 0.015 mg/kg. The mean recoveries at three spiked concentration levels (0.05, 0.10 and 0.50 mg/kg) were in the range of 85.9%–102.1% with relative standard deviations (RSDs,n = 6) ranging from 2.4% to 5.6%. The proposed method showed the advantages of high sensitivity, good clean-up efficiency and high accuracy, and it was suitable for the detection of chloropropanol esters in infant formula milk powder.关键词
气相色谱-质谱法/婴幼儿配方乳粉/氯丙醇酯/固相萃取Key words
gas chromatography-mass spectrometry (GC-MS)/infant formula milk powder/chloropropanol esters/solid phase extraction分类
化学化工
