食品科学2017，Vol.38Issue(17)：174-183,10.DOI:10.7506/spkx1002-6630-201717029
植物甾醇及添加植物甾醇乳制品降低心脑血管疾病风险的功能性评价
Evaluation of the Efficacy of Phytosterol and Phytosterol-Supplemented Dairy Products in Reducing the Risk of Cardiovascular and Cerebrovascular Diseases
摘要
Abstract
The present study aimed to evaluate the efficacy of phytosterol (PS), phytosterol ester (PSE) and dairy products supplemented with PS and/or PSE in reducing the risk of cardiovascular and cerebrovascular diseases for the purpose of providing a scientific basis for guiding the practical use of plant-derived phytochemicals and Yangxin dairy (YXD), a commercial dairy product supplemented with both PS and PSE. SD rats were randomly divided into 9 groups with 10 rats in each group. The rats in the normal control and model groups were fed a normal diet and a high fat diet, respectively and then administrated by gavage with 0.9% normal saline, while those in the PS, PSE, YXD and placebo groups were given a high fat diet and gavaged with PS at 23.6 and 47.2 mg/mL, PSE at 23.6 and 47.2 mg/mL, YXD at 30 and 60 g/250 mL and peanut oil, respectively. After 4 consecutive weeks of administration, all the rats were sacrificed for the collection of blood and visceral tissue samples. The results showed that total serum cholesterol levels in the rats in the PS, PSE and YXD groups significantly decreased and serum high-density lipoprotein cholesterol levels increased in a dose-dependent manner compared with the model group. These treatments also caused a reduction of triglyceride, total antioxidant capacity and malonaldehyde levels, although the effect was unstable. The same trends were also seen for the corresponding indicators in liver and pathological sections. PSE and YXD had better efficacy in reducing the risk of cardiovascular and cerebrovascular diseases. Furthermore, YXD had higher potential to reduce the risk of cardiovascular diseases and protect the liver and blood vessels.关键词
植物甾醇/植物甾醇酯/心脑血管疾病/降胆固醇Key words
phytosterols/phytosterol ester/cardiovascular and cerebrovascular diseases/cholesterol-reducing分类
轻工纺织引用本文复制引用
明珠,陈庆森,张蕾,闫亚丽,赵培..植物甾醇及添加植物甾醇乳制品降低心脑血管疾病风险的功能性评价[J].食品科学,2017,38(17):174-183,10.基金项目
国家自然科学基金面上项目(31071522) （31071522）
天津市教委面上项目(20120603) （20120603）
