茶叶科学2017，Vol.37Issue(5)：429-441,13.
绿茶儿茶素类生物标记物的检测及应用
Determination of Green Tea Catechin Biomarkers and It′s Relative Application
摘要
Abstract
Green tea has been considered to have many health benefits, but there is still controversy about the clinical and epidemiological results. Development of green tea catechin biomarkers was to evaluate the physiological effects of green tea from a metabolic point of view, which will be helpful to interpret the functional mechanism of green tea in vivo and also avoid or reduce the influences of chemical compositions of samples intake or individual differences in human studies. Catechin compounds EGCG, EGC, EC, C, ECG and their derivatives are common green tea catechin biomarkers that have many determination methods including HPLC-EC, LC-MS and so on. This paper reviewed the types of green tea catechin biomarkers and their preparation and determination methods, discussed the results of biomarker-level based bioavailability studies, clinical trials and epidemiological studies, proposed suggestions for future research, such as further improvement and standardization of the preparation and determination methods of catechin biomarkers as well as development of new green tea biomarkers with higher stability in human body and sensitivity in reflecting their intake levels.关键词
绿茶儿茶素类生物标记物/HPLC-EC/儿茶素化合物/EGCG/代谢产物/流行病学/综述Key words
green tea catechin biomarker/HPLC-EC/catechin compounds/EGCG/metabolites/epidemiology/review分类
轻工纺织引用本文复制引用
孙丽丽,曾祥泉,Nilesh W Gaikwad,王欢,须海荣,叶俭慧..绿茶儿茶素类生物标记物的检测及应用[J].茶叶科学,2017,37(5):429-441,13.基金项目
美国农业部国家粮食和农业研究所专项基金(#CA-D-NTR-2104-H)、国家留学基金委国家公派硕士研究生项目基金[2015]3024 （#CA-D-NTR-2104-H）
