现代食品科技2017，Vol.33Issue(9)：8-12,133,6.DOI:10.13982/j.mfst.1673-9078.2017.9.002
沙棘粉对大鼠肝脏脂质代谢及氧化应激的影响
Effect of Sea Buckthorn Powder on Hepatic Lipid Metabolism and Oxidative Stress in Rats
摘要
Abstract
The effects of sea buckthom powder on the hepatic lipid metabolism and oxidative stress in rats were studied in this paper.Fifty male Wistar rats were randomly divided into five groups:the control group;the high fat/cholesterol diet group;and sea buckthom powder low-,medium-,and high-dose groups.The control group was fed with basal diet,and other groups were fed with high fat/cholesterol diet during the experiment.The rats in both control and high fat/cholesterol diet groups were given distilled water,and those in low-,medium-,and high-dose treated groups were given sea buckthom powder at doses of 0.5 mg/g·body weight (bw),2.5 mg/g·bw,and 5 mg/g·bw,respectively.The animals were sacrificed after four weeks,and livers were collected to measure the liver lipid content,lipid metabolism-related enzyme activity,and oxidative stress level.The results indicated that compared with the high fat/cholesterol diet group,sea buckthorn powder reduced the levels of hepatic total cholesterol (TC),total triglyceride (TG),and malondialdehyde (MDA),and increase the levels of high density lipoprotein-cholesterol (HDL-C) and glutathione (GSH) and the activities of hepatic lipase (HL),lipoprotein lipase (LPL),and total superoxide dismutase (T-SOD).These results demonstrated that sea buckthom powder could reduce the liver lipid levels,improve lipid metabolism enzyme activities in the liver,increase antioxidant capacity,and slow down lipid peroxidation in hepatocytes of high-fat diet-fed rats.关键词
沙棘粉/肝脏/脂质代谢/肝脂酶/氧化应激Key words
sea buckthorn powder/liver/lipid metabolism/hepatic lipase/oxidative stress引用本文复制引用
杜鹃,郗艳丽,宋春梅..沙棘粉对大鼠肝脏脂质代谢及氧化应激的影响[J].现代食品科技,2017,33(9):8-12,133,6.基金项目
吉林省科技发展计划项目(20170623093-10TC) （20170623093-10TC）
