食品科学2017，Vol.38Issue(20)：161-168,8.DOI:10.7506/spkx1002-6630-201720023
响应面试验优化羟丙基-β-环糊精包合植物甾醇的水溶性改性工艺
Optimization of Preparation of Inclusion Complex of Phytosterol with Hydroxypropyl-β-Cyclodextrin for Improved Water Solubility by Response Surface Methdology
摘要
Abstract
In this study,phytosterol (PS) was included with hydroxypropyl-β-cyclodextrin (HP-β-CD) to improve its solubility and thereby broaden the range of its application in the food industry.The inclusion complex was tested by differential scanning calorimetry (DSC),Fourier transform infrared (FT-IR) spectroscopy and X-ray diffraction.The inclusion process was optimized using response surface methodology.The optimum conditions obtained were as follows:molar ratio between PS and HP-β-CD,4.27∶1;temperature,47 ℃;and inclusion time,11.93 h,yielding an inclusion rate of 96.57％.However,to improve operating convenience,these parameters were modified as 4.30∶1,47 ℃,and 12 h,respectively.Triplicate experiments carried out under these conditions gave an average inclusion rate of up to 97.25％.At 37 ℃;the water solubility of HP-β-CD/PS clathrate reached an average of 8.31 mg/mL,which was 307.90 times of its original solubility (0.027 mg/mL).关键词
植物甾醇/羟丙基-β-环糊精/包合/溶解度Key words
phytosterol/hydroxypropyl-β-cyclodextrin/inclusion/solubility分类
轻工纺织引用本文复制引用
郑雯,王远,袁田青,蔡珺珺,宫兴文..响应面试验优化羟丙基-β-环糊精包合植物甾醇的水溶性改性工艺[J].食品科学,2017,38(20):161-168,8.基金项目
浙江省自然科学基金项目(LY12C19011) （LY12C19011）
食品科学与工程浙江省重中之重一级学科资助项目(JYTSP20141052) （JYTSP20141052）
