食品与发酵工业2017，Vol.43Issue(10)：256-262,7.DOI:10.13995/j.cnki.11-1802/ts.014789
纳豆激酶液态发酵生产的研究进展
Research progress of liquid fermentation of nattokinase
摘要
Abstract
Nattokinase(EC3.4.21.62)is a kind of serine proteinase that has potent thrombolytic activity.Compared to the first-line thrombolytic drugs (urokinase and streprokinase),nattokinase possesses several advantages such as safety,low cost,long half-life and easy oral administration.Therefore,nattokinase has been receiving increasing attention for its use as thrombolytic agent or health care product.The solid and liquid fermentation sare usually employed for the nattokinase production.However,the fermentation titer of nattokinase is still poor,and can meet the requirement of the market.In this review,the strain breeding,medium optimization,fermentation conditions optimization,and culture mode of nattokinase have been outlined and summarized,which would provide valuable reference for the industrial production and application of nattokinase.关键词
纳豆激酶/微生物/液态发酵/溶栓药物Key words
nattokinase/microorganism/liquid fermentation/thrombolytic drug引用本文复制引用
吴燕,李英波,梁向峰,刘会洲,肖建辉..纳豆激酶液态发酵生产的研究进展[J].食品与发酵工业,2017,43(10):256-262,7.基金项目
中国科学院绿色过程与工程实验室青年基金(GPE-2013-3) （GPE-2013-3）
贵州省高层次创新型人才支撑计划(QKH-RC-20154028) （QKH-RC-20154028）
国家自然科学基金(81460156) （81460156）
