现代食品科技2017，Vol.33Issue(10)：1-6,6.DOI:10.13982/j.mfst.1673-9078.2017.10.001
紫薯提取物对秀丽隐杆线虫寿命的影响
Effects of Purple Sweet Potato Extract on the Lifespan of Caenorhabditis Elegans
摘要
Abstract
Effects of Purple sweet potato extract (PSPE) on the lifespan of Caenorhabditis elegans (C.elegans) and its possible mechanism were studied.C.elegans were fed in normal culture medium and NGM culture medium containing different concentrations (70,140,280 μg/mL) of PSPE to investigate the effects of PSPE on the lifespan of C.elegans as well as the content of lipofuscin,superoxide dismutase (SOD) and catalase (CAT) and the expressions of antioxidant-related genes in vivo.The Results showed that the average lifespan of C.elegans fed with 280 μg/mL PSPE increased by 33％,he accumulation of lipofuscin decreased by 30％,the activity of SOD and CAT increased by 17.7％ and 47.5％,respectively,compared with the blank group.The mRNA levels of daf-16,ctl-1 and sod-3 in nematodes were increased in different degrees,and the mRNA expressions ofdaf-16,ctl-1 and sod-3 in 280 μg/mL PSPE group were increased by 23.2％,37.4％ and 84.6％,respectively;While the mRNA expression of age-1 in 280 μg/mL PSPE group was decreased by 26.4％.关键词
秀丽隐杆线虫/紫薯提取物/抗氧化/抗衰老Key words
Caenorhabditis elegans/purple sweet potato extract/antioxidantion/anti-aging引用本文复制引用
李祥,张泽生,汤新慧,康贻军,王慧,杨胜楠,王浩..紫薯提取物对秀丽隐杆线虫寿命的影响[J].现代食品科技,2017,33(10):1-6,6.基金项目
国家自然科学基金应急管理项目(31540086) （31540086）
