食品科学2017，Vol.38Issue(21)：212-216,5.DOI:10.7506/spkx1002-6630-201721034
芸豆芽菜多酚对氧化损伤小鼠体内抗氧化及肝脏损伤修复作用
Effects of Kidney Bean Sprout Polyphenols on Restoring Antioxidant System and Oxidative Liver Injury in Mice
摘要
Abstract
This experiment explored the effect of kidney bean sprout polyphenols on restoring the antioxidant system and D-galactose-induced liver injury in mice.Intraperitoneal injection of D-galactose solution was conducted to construct a mouse model of oxidative injury.Body weight,liver coefficient and superoxide dismutase (SOD),glutathione peroxidase (GSH-Px),alanine aminotransferase (ALT) and aspartate transaminase (AST) activities and malondialdehyde (MDA) concentration in serum were determined after 28 days of continuous administration of different doses (20、40、60 mg/(kg·d)) of kidney bean sprout polyphenols,and liver tissue sections were stained with hematoxylin-eosin and examined for the degree of liver damage and recovery.Compared with the model control group,oral administration of kidney bean sprout polyphenols showed no significant differences in body weight or liver coefficient (P ＞ 0.05);however,serum SOD and GSH-Px activities in the middle-and high-dose groups were increased significantly (P ＜ 0.05),MDA concentration was decreased significantly (P ＜ 0.05),and the liver function indicators ALT and AST activities were reduced significantly (P ＜ 0.05).Histopathological observation indicated that swollen hepatocytes were restored to normal by the administration of kidney bean sprout polyphenols and the number of intercellular bleeding points and inflammatory cell infiltration were reduced dose-dependently.关键词
芸豆芽菜多酚/D-半乳糖/氧化损伤/肝脏/修复作用Key words
kidney bean sprout polyphenols/D-galactose/oxidative damage/liver/restoring effect分类
轻工纺织引用本文复制引用
王颖,佐兆杭,王欣卉,徐炳政,朱磊,刘淑婷,宫雪..芸豆芽菜多酚对氧化损伤小鼠体内抗氧化及肝脏损伤修复作用[J].食品科学,2017,38(21):212-216,5.基金项目
大庆市科技局创新项目(sjh-2013-65) （sjh-2013-65）
国家星火计划项目(2015GA670008) （2015GA670008）
黑龙江省应用技术研究与开发计划重大项目(GA15B301)黑龙江八一农垦大学研究生创新科研项目(YJSCX2017-Y56 （GA15B301）
YJSCX2017-Y57) （）
