食品科学2017，Vol.38Issue(21)：279-286,8.DOI:10.7506/spkx1002-6630-201721044
老年人肌少性肥胖的机制与运动营养调控研究进展
Exercise and Nutrition Interventions of Sarcopenic Obesity and Underlying Mechanisms
摘要
Abstract
Sarcopenic obesity (SO) is a progressive disease characterized by obesity accompanied by declining skeletal muscle mass and/or strength in aging populations,which seriously affects the quality of life of patients.A large number of studies have shown that the body composition of the elderly could gradually change with age,even if the body weight remains at the same level,skeletal muscle mass and functions could decrease and fat deposition could increase mainly in muscle tissues and visceral organs,leading to increased accumulation of intramuscular fat,accelerated secretion of inflammatory phenomena,reduced level of growth hormones,deficient intake of nutrients,increased daily physical inactivity,degenerated neuronal function,and improved insulin resistance,which are highly associated with sarcopenic obesity.Based on the molecular underlying molecular mechanisms,protein synthesis and degradation,glucose and lipid metabolism and related cytokines in skeletal muscle are involved in the regulation of skeletal muscle metabolism during sarcopenic obesity.Exercise intervention,calorie restriction,and consumption of proteins,vitamin D,β-hydroxy-β-methyl-butyrate (HMB),creatine and whey protein can play an important role in the prevention and treatment of sarcopenic obesity.Although the number of population with sarcopenic obesity increases,the pathogenesis of sarcopenic obesity is inconsistently understood and inconsistent evaluation criteria and prevention and treatment strategies for this disease are used by researchers,causing great diffculties in studying sarcopenic obesity.In this article,we summarize and discuss the literature to date regarding the definition,pathogenesis and related signal pathways of sarcopenic obesity,as well as the corresponding prevention and treatment strategies (exercise or nutrition interventions),which will provide a novel insight into the prevention and treatment of sarcopenic obesity.关键词
肌少性肥胖/病理机制/信号调控通路/防治策略Key words
sarcopenic obesity/pathogenesis/signal pathway/prevention and treatment strategies分类
医药卫生引用本文复制引用
徐磊,李春艳,陈宁,范晶晶..老年人肌少性肥胖的机制与运动营养调控研究进展[J].食品科学,2017,38(21):279-286,8.基金项目
国家自然科学基金面上项目(31571228) （31571228）
国家体育总局科教司科学研究项目(2014B093) （2014B093）
湖北省高等学校优秀中青年科技创新团队项目(T201624) （T201624）
湖北省体育教育与健康促进学科群项目 （）
