现代食品科技2017，Vol.33Issue(11)：102-109,8.DOI:10.13982/j.mfst.1673-9078.2017.11.016
王浆酸冻干粉的安全性毒理学评价
Toxicological Safety Evaluation of Royal Jelly Acid Lyophilized Powder
摘要
Abstract
The safety of lyophilized powder of royal jelly acid was studied for the reasonable utilization and development of eleutheroside.According to the national standard procedures and methods in food safety and toxicological evaluation,a series of toxicological studies on the ingestion of eleutheroside were conducted,including the acute oral toxicity test in mice,genetic toxicity tests (salmonella typhimurium reverse mutation test (Ames test),mouse bone marrow cell micronucleus test and mouse sperm malformation test) and a 30-day feeding test in rats.Oral acute toxicity test showed that the medium lethal dose (LD50) of the powder was above 20 mg/kg·bw for both male and female mice.The results of Ames test,mouse bone marrow micronucleus test and spermabnorinality test were negative.The 30-day feeding test showed that the physical appearance and indices of hematology,biochemistry,organ coefficients and histological observations of rats had no significant differences as compared with the control group.关键词
王浆酸/急性毒性/遗传毒性/30d喂养实验/毒理学评价Key words
royal jelly acid/toxicology evaluation/acute toxicity test/genotoxicity test/30-day feeding test引用本文复制引用
白冰瑶,周茜,杨光,董小涵,闫晨静,韩雪,蔡东伟,赵文..王浆酸冻干粉的安全性毒理学评价[J].现代食品科技,2017,33(11):102-109,8.基金项目
河北省科技计划项目(17236405D) （17236405D）
河北省食品科学与工程学科“双—流”建设资金项目(2016SPGCA18) （2016SPGCA18）
