乳业科学与技术2017，Vol.40Issue(4)：15-19,5.DOI:10.15922/j.cnki.jdst.2017.04.004
稳定同位素内标-高效液相色谱-串联质谱法测定婴幼儿食品中双酚类化合物
Evaluation of Bisphenols Residues in Infant Foods by High Performance Liquid Chromatography-Tandem Mass Spectrometry Using Stable Isotope Internal Standard
耿宁 1卢剑2
作者信息
- 1. 江苏省质量协会,江苏 南京 210029
- 2. 江苏省产品质量监督检验研究院,江苏 南京 210007
- 折叠
摘要
Abstract
An isotope internal standard coupled with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was established for the simultaneous determination of four bisphenols (bisphenols A, B, F and S) in infant foods. Samples were extracted with a mixture of ethyl acetate and cyclohexane and detected by HPLC-MS/MS in the multi-reaction monitoring mode. Under the optimized conditions, the four bisphenols showed good linearity in the range of 5.0–200.0 μg/L with R2 larger than 0.9970. The detection limit of the method was 1.5 μg/kg. The mean recoveries of negative samples spiked at three concentration levels (5.0, 10.0 and 50.0 μg/L) were in the range of 84.0％–106.5％with relative standard deviations (RSDs, n = 6) ranging from 1.6％ to 6.4％. The proposed method had the advantages of high sensitivity, good purification efficiency and quantitative accuracy and it was suitable for the detection of bisphenols in infant foods.关键词
高效液相色谱-串联质谱法/双酚类化合物/婴幼儿食品/环境激素Key words
high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)/bisphenols/infant foods/environmental hormones分类
化学化工引用本文复制引用
耿宁,卢剑..稳定同位素内标-高效液相色谱-串联质谱法测定婴幼儿食品中双酚类化合物[J].乳业科学与技术,2017,40(4):15-19,5.
