中国食物与营养2017，Vol.23Issue(7)：71-75,5.
海参胶原低聚肽对糖尿病小鼠术后伤口愈合的促进作用
Effect of Sea Cucumber Collagen Oligopeptide in Diabetic Wound Healing
摘要
Abstract
[Objective] To observe the effect of sea cucumber collagen oligopeptide on the wound healing of diabetic mice,and to provide experimental basis for the further study on the relationsfip between sea cucumber collagen oigopeptide and diabetic wound healing.[Method] Totally 90 db/db mice were divided into 5 groups,including modal control group,whey protein group (0.50g/kg · BW) and 3 sea cueumber collagen oligopeptide dose groups (0.25,0.50,1.00 g/kg · BW).Each group included 18 mice.A group of 18 db/m mice with the same age and gender was selected as the blank control group.The model control group and dhe normal control group were treated with solvent.The intervention was carried out after the incision operation on the back of mice,and the animals were sacrificed at day 4,7 and 14,respectively.We observed the wound healing condition every day after operation.The serum bioehemical indexes were measured.The tensile strength of the wound was measured and the skin HE staining was perfonned.[Result] Compared with the model control group,the tension strength of sea cucumber oligopeptide dose groups increased significantly.Pathological report showed that neutrophil granulocyte in the sea cucunder peptide dose groups decreased while blood capillary and fibroblasts increased.After the intervention,the detection of serum inflammation index IL-8 significantly decreased (P ＜0.05) while IL-10 increased (P ＜0.05).NO level was significantly increased (P＜0.05).[Conclusion] Sea cucumber collagen oligopeptide can enhance wound tensile strength,promote angiogenesis,reduce inflammation of diabetic nfce,thereby promoting wound healing.关键词
海参胶原低聚肽/糖尿病/伤口愈合Key words
sea cucumber oligopeptide/diabetes mellitus/wound healing引用本文复制引用
李林,李迪,徐腾,刘睿,任金威,陈启贺,李勇..海参胶原低聚肽对糖尿病小鼠术后伤口愈合的促进作用[J].中国食物与营养,2017,23(7):71-75,5.基金项目
国家自然科学基金(项目编号:81573138). （项目编号:81573138）
