CT理论与应用研究2018，Vol.27Issue(1)：77-84,8.DOI:10.15953/j.1004-4140.2018.27.01.10
X线检查发现病理性骨折对骨肉瘤预后的影响分析
Pathologic Fracture Predicts for Poor Prognosis in Osteosarcoma for Recurrence and Amputation Based on X-ray
郝运 1何金鹏2
作者信息
- 1. 华中科技大学同济医学院附属同济医院放射科,武汉430030
- 2. 华中科技大学同济医学院附属同济医院小儿外科,武汉430030
- 折叠
摘要
Abstract
Objective:The significance of pathologic fracture and prognosis for osteosarcoma is still controversial. The aim was to provide a Meta-analysis for pathologic fracture and prognostic features of osteosarcoma patients. Methods:A detailed search was made in MEDLINE, EMBASE and the Web of Knowledge for relevant original articles published in English; methodological quality of the included studies was also assessed. Two reviewers extracted data independently. Studies were pooled and odds ratio (ORs) with corresponding confidence intervals (CIs) were calculated. Results:Pool analysis of 1502 patients from 5 eligible studies was performed. Combined OR of pathologic fracture indicated that pathologic fracture was associated with local recurrence (n=1018 in 4 studies;OR=1.83;95％CI:1.06～3.15;P=0.03) and the limb salvage (n=1502 in 5 studies;OR=1.84;95％CI:1.25～2.72;P=0.002) but not with adequate margin (n=1501 in 5 studies;OR=0.74;95％CI:0.39～1.40;P=0.35) or histological response to neoadjuvant chemotherapy (n=1420 in 4 studies; OR=0.41; 95％ CI:0.98～2.05;P=0.07). Conclusion:The results of this Meta-analysis indicate that a higher risk of local recurrence and amputation were achieved in osteosarcoma patients with pathological fracture than those without pathological fracture. The pathologic fracture is a predictor of poor prognosis in osteosarcoma.关键词
骨肉瘤/病理性骨折/复发/截肢/预后Key words
osteosarcoma/pathological fracture/recurrence/amputation/prognosis分类
医药卫生引用本文复制引用
郝运,何金鹏..X线检查发现病理性骨折对骨肉瘤预后的影响分析[J].CT理论与应用研究,2018,27(1):77-84,8.
