食品工业科技2017，Vol.38Issue(22)：22-25,30,5.DOI:10.13386/j.issn1002-0306.2017.22.005
虾青素对秀丽隐杆线虫衰老的改善作用及机制研究
The aging improvement effects and mechanism of astaxanthin on Caenorhabditis elegans
罗婧 1沈紫龙 1任建武1
作者信息
- 1. 北京林业大学生物科学与技术学院,北京100083
- 折叠
摘要
Abstract
In this study,the mechanism of the aging improvement of astaxanthin on Caenorhabditis elegans was studied by lifespan extension analysis,oxidative stress,and heat stress analyses.Astaxanthin-treated groups (0.8,1.2,and 1.6 mmol/L) were compared to the control group to explore the anti-aging effect of different concentrations in wild-type nematode and identify the optimal dose according to mean and maximum lifespan extension.The optimal dose of astaxanthin was 1.2 mmol/L,at which dose astaxanthin prolonged mean lifespan of wild type nematode by 41.79％ (p ＜ 0.01) and increased maximum lifespan by 32.72％ (p ＜ 0.01).The possible mechanisms of astaxanthin's aging effects were further studied using the 1.2 mmol/L treatment to test its impact on resistance to heat and oxidative stress.The mean survival times of astaxanthintreated wild type nematode after oxidative and heat stress were increased by 22.54％ and 24.23％ (p ＜ 0.01),respectively.In oxidative stress and heat stress experiments,1.2 mmol/L astaxanthin could significantly increase the survival time of the sir-2.1 mutant nematodes,but had no significant effect on daf-2,daf-16,or eat-2 mutants.The above results suggested that astaxanthin can prolong the lifespan of nematodes by increasing stress tolerance and its mechanism may be related to the insulin signaling and diet-restriction pathways.关键词
虾青素/秀丽隐杆线虫/衰老Key words
astaxanthin/Caenorhabditis elegans/aging分类
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罗婧,沈紫龙,任建武..虾青素对秀丽隐杆线虫衰老的改善作用及机制研究[J].食品工业科技,2017,38(22):22-25,30,5.
