食品科学2018，Vol.39Issue(1)：1-15,15.DOI:10.7506/spkx1002-6630-201801001
食品营养与免疫代谢关系研究进展
On the Relationship between Food Nutrition and Immunometabolism
摘要
Abstract
A growing number of studies on food nutrition and function are concentrated on the metabolic and immunomodulatory effects,which have become the focus of diet and health research.Obesity,type 2 diabetes mellitus (T2DM),hyperlipidemia and cancer as diseases associated with modern lifestyle have become a public health problem which scientists have to face.Scientists once believed that these diseases can be overcome by immunotherapy and chemotherapy.Unfortunately they also found that the activation and reproduction of immune cells depend on glucose leading to aerobic glycolysis (Warburg effect) similarly as do diabetes and cancer.This means that when the immune system is activated,cancer cells may also be activated.Moreover,when immune cells migrate to the cancer microenvironment,immunosuppression or immune anergy may occur.Apparently,immune activity is closely related to cellular signal transduction and metabolism,both of which experience a nutrient sensing-dependent metabolic reprogramming and aerobic glycolysis.Therefore,scientists define the term "immunometabolism" to describe the metabolic reprogramming of immune cells upon activation,aiming to find the control mechanism and inner linkage between Warburg effect and immune cell activity and further to seek a new avenue for the prevention and treatment of these diseases.In this review,we focus on immunometabolism and future prospects of functional food and nutrition.关键词
免疫代谢/功能性食品/营养/现代生活方式症/瓦氏效应/代谢重编程Key words
immunometabolism/functional food/nutrition/modern lifestyle-related diseases/Warburg effect/metabolic reprogramming分类
医药卫生引用本文复制引用
庞广昌,陈庆森,胡志和,解军波..食品营养与免疫代谢关系研究进展[J].食品科学,2018,39(1):1-15,15.基金项目
国家自然科学基金面上项目(31671857 （）
31371773) （）
