食品科学2018，Vol.39Issue(1)：226-231,6.DOI:10.7506/spkx1002-6630-201801034
葡萄籽多酚对糖尿病大鼠的降血糖作用及其机制
Hypoglycemic Effect of Grape Seed Polyphenols in Diabetic Rats and Its Underlying Mechanism
摘要
Abstract
Objective:To investigate anti-diabetic effect of grape seed polyphenols (GSP) in type Ⅱ diabetic rats,and to illustrate its underlying mechanism from the perspective of pancreatic islet damage and insulin expression.Methods:A rat model of type Ⅱ diabetes was established by injecting streptozotocin (STZ) to male SD rats.The diabetic rats were randomly divided to STZ model group,GSP treatment group (50 mg/(kg·d)),and acarbose treatment group (positive control group).GSP was administrated to diabetic rats at a dose of 50 mg/kg mb per day for 8 weeks.Serum glucose,insulin,oral glucose tolerance test (OGTT),serum superoxide dismutase (SOD) and malondialdehyde (MDA) were tested after the last administration.Islet cell damage and insulin expression were detected using immunohistochemical staining.Results:GSP decreased serum glucose level,increased OGTT,and promoted insulin secretion in diabetic rats (P ＜ 0.05).In addition,GSP improved STZ-induced islet cell damage and increased insulin expression (P ＜ 0.05).Serum SOD activity was increased by administration of GSP,while MDA content was decreased significantly (P ＜ 0.05).Conclusion:A long-term intervention with low-dose GSP can effectively regulate blood glucose in diabetic rats.GSP promotes insulin secretion by rescuing islet cell damage,thereby decreasing fasting serum glucose level and increasing OGTT,which may be associated with its potent antioxidant activity in vivo.关键词
葡萄籽多酚/降血糖/胰岛素/胰岛细胞损伤Key words
grape seed polyphenols/hypoglycemia/insulin/islet cell damage分类
轻工纺织引用本文复制引用
仇菊,朱宏,卢林纲..葡萄籽多酚对糖尿病大鼠的降血糖作用及其机制[J].食品科学,2018,39(1):226-231,6.基金项目
中国农业科学院科技创新工程项目 （）
