摘要
Abstract
An efficient ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was established for the simultaneous analysis of residues of 8 antiviral drugs (arbidol,amantadine,rimantadine,famciclovir,peramivir,imiquimod,oseltamivir,and lamivudine) in chicken meat and liver and pork meat and liver.Samples were extracted with 1％ formic acid-acetonitrile,and the extract was subjected to chromatographic separation on MCX solidphase extraction column.Quantification of the analytes was achieved by UPLC-MS/MS using the internal standard method.The limit of detection (LOD) and limit of quantification (LOQ) of the method were lower than 1.0 and 3.0 μg/kg for all the antiviral drugs,respectively.The average recoveries of 8 antiviral drugs in blank chicken meat,pork meat,chicken liver and pork liver at spiked levels of 5.0,10.0,and 20.0 μg/kg ranged from 70％ to 120％,with relative standard deviation (RSD) of less than 10％.The method had the advantages of small matrix interference,high sensitivity and good recovery.Therefore,it can be used for the detection of antiviral drugs residues in animal-derived food.关键词
抗病毒类药物/超高效液相色谱-串联质谱/鸡肉/鸡肝/猪肉/猪肝Key words
antiviral drugs/ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)/chicken meat/chicken liver/pork meat/pork liver分类
轻工纺织
