食品工业科技2017，Vol.38Issue(23)：262-267,274,7.DOI:10.13386/j.issn1002-0306.2017.23.048
牛初乳冻干粉和常乳冻干粉的降血糖及抗氧化作用
Hypoglycemic and antioxidation effect of lyophilized bovine colostrums and lyophilized milk
摘要
Abstract
Objective:To study on hypoglycemic effect and antioxidative effects of lyophilized bovine colostrums (LBC) and lyophilized milk(LM).Methods:The free radical scavenging activity,IGFs and insulin content were detected by biochemical analysis.Alloxan diabetes model was induced in mice where rats were treated with Phenformin(100 mg/kg),LM(600 mg/kg) and LBC(100、600 mg/kg)respectively.Besides,normal mice were used as control.The blood glucose,glucose tolerance and antioxidant and other indicators were measured after 30 days.Results:The EC50 of scavenging superoxide free radicals and DPPH free radicals were respectively 245.3,167.2 μg/mL in LBC.The content of IGF-I,IGF-Ⅱ and insulin of LBC were 1146.5,1303.0,128.4 ng/g respectively.LM had a part of scavenging effect on hydroxyl free radicals,and the content of IGFs was significantly lower than LBC and insulin was not detected.LBC made significantly improvement on diabetic mice,significantly lower blood glucose levels,reduced the content of MDA and TC in serum,enhanced the tolerance and blood SOD activity.LM had no significant improvement in blood glucose level and antioxidant index.Conclusion:LBC included higher hypoglycemic factors,producted exhibited strong radical-scavenging activity in vivo than LM,which has hypoglycemic and antioxidative effects on diabetic mice.关键词
牛初乳冻干粉/常乳冻干粉/降血糖/类胰岛素生长因子/抗氧化作用/小鼠Key words
lyophilized bovine colostrums/lyophilized milk/hypoglycemic effect/insulin-like growth factor/antioxidation/mice分类
轻工纺织引用本文复制引用
王小军,葛文金,王荣昌,程光宇,高睿嘉,郁桦,狄怡琳,李玲,王艺茗,丁宁,魏扬智,于天阳..牛初乳冻干粉和常乳冻干粉的降血糖及抗氧化作用[J].食品工业科技,2017,38(23):262-267,274,7.基金项目
国家自然科学基金项目(31500373) （31500373）
江苏省品牌专业支助(PPZY2015B117). （PPZY2015B117）
