食品工业科技2017，Vol.38Issue(23)：275-279,283,6.DOI:10.13386/j.issn1002-0306.2017.23.050
植物乳杆菌KLDS 1.0386对C57BL/6小鼠胆固醇代谢的影响
Effect of Lactobacillus Plantarum KLDS 1.0386 on the cholesterol metabolism in C57BL/6 mice
摘要
Abstract
Objective:It was evaluated that the effect of Lactobacillus plantarum KLDS strain on the cholesterol metabolism *n hyperlipidemia mice and zhe ability under simulated gastric and intestinal juice.Method:Viable count was used to detect the tolerance characteristics under simulated gastric and intestinal juice environment.Health C57BL/6 male mice,as objects,were divided into control group,model group,low-dose group,high-dose group and pravastatin group,which were respectively given normal saline,Lactobacillus plantarum KLDS 1.0386 bacteria suspension and pravastatin solution by gavage for 4 consecutive weeks.The liver levels of total cholesterol (TC),triglyeeride (TG) and the feces levels of TC,total bile acid (TBA) were determined on the 28th day of the experiment.Results:It showed that the tolerance rate in gastric juice pH3.0 was 92.62％,and the intestinal juice was 83.91％,so,Lactobacillus plantarum KLDS 1.0386 can pass the stomach into the intestines and keep active in the gut.After 4 weeks administration,compared with mice fed a high-cholesterol diet without lactic acid bacteria supplementation,there was a significant(p ＜ 0.05)decrease in triglyeeride and total cholesterol levels in the hepatic of mice treated with KLDS 1.0386 strain.Furthermore,total cholesterol and total bile acid levels in the feces were significantly(p ＜0.05) increased after KLDS 1.0386 administration.Concluton:Lactobacillus plantarum KLDS 1.0386 could be as the probiotics with cholesterol-lowering activity.关键词
植物乳杆菌/胃液/肠液/胆固醇/胆汁酸Key words
Lactobacillus plantarum/gastric juice/intestinal juice/cholesterol/bile acid分类
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靳妲,于上富,李柏良,李娜,闫芬芬,霍贵成..植物乳杆菌KLDS 1.0386对C57BL/6小鼠胆固醇代谢的影响[J].食品工业科技,2017,38(23):275-279,283,6.基金项目
国家重点研发计划(2017YFD0400300). （2017YFD0400300）
