食品工业科技2017，Vol.38Issue(23)：284-288,5.DOI:10.13386/j.issn1002-0306.2017.23.052
洋葱槲皮素对脂多糖诱导的小鼠腹腔巨噬细胞炎症反应抑制作用
Inhibiting effect of onion quercetin on lipopolysaccharide-induced mice's enterocoelia macrophage inflammatory response
摘要
Abstract
To discuss the inhibiting effect of onion quercetin on inflammatory response,this paper took mice's enterocoelia macrophage as sample and used MTT to investigate the impact of onion quercetin single drug group,combination drug of onion quercetin and LPS group on macrophage's phagocytosis,used ELISA to investigate the impact of onion quercetin single drug group,combination drug of onion quercetin and LPS group on cytokines and inflammatory mediator secretion from mice's enterocoelia macrophage.The result showed that onion quercetin can improve phagocytosis of macrophage;onion quercetin single drug and combination drug of onion quercetin and LPS can stimulate macrophage of IL-1β and COX-2 which induces secretion of macrophage.In summary,onion quercetin may inhibit inflammation via improving macrophage's phagocytosis and affecting secretion of cytokines and inflammatory mediator.关键词
洋葱槲皮素/巨噬细胞/细胞因子/炎症介质/抗炎Key words
onion quercetin/macrophages/cytokines/inflammatory mediator/anti-inflammatory分类
轻工纺织引用本文复制引用
倪湾,李敬双,于洋..洋葱槲皮素对脂多糖诱导的小鼠腹腔巨噬细胞炎症反应抑制作用[J].食品工业科技,2017,38(23):284-288,5.基金项目
辽宁省科技厅-锦州医科大学联合基金项目(20170540357) （20170540357）
辽宁省大学生创新创业训练计划项目(201610160000055,201610160000011). （201610160000055,201610160000011）
