食品工业科技2017，Vol.38Issue(24)：303-307,5.DOI:10.13386/j.issn1002-0306.2017.24.059
牡蛎内脏多糖抗氧化活性及对四氯化碳所致小鼠急性肝损伤的影响作用
Antioxidant activity and hepatoprotective effects of polysaccharide from Crassostrea gigas internal organs against CCl4 induced hepatic injury in mice
摘要
Abstract
Objective:To investigate the protective effect of polysaccharide from Crassostrea gigas internal organs (CGOP)on acute liver injury induced by CCl4 in mice.Methods:CGOP was analyzed effects of antioxidant action by scavenging DPPH free radical,hydroxyl free radical,ABTS radical and reduction potential.ALT,AST levels in serum and MDA,SOD levels in liver tissues were examined.In addition,pathologic changes were examined by HE staining.Results:CGOP showed antioxidant abilities.And acute hepatic injury protections of CGOP were demonstrated by the fact that increased in activity of liver AST and ALT caused by CCl4 of mice treated were significantly inhibited while the MDA content was significantly lowered and SOD activity enhanced as well.Histopathological changes induced by CCl4 were also significantly reduced.The results indicated that CCl4 acute liver damages could be inhibited by CGOP.It provides the basic data for making better use of oyster resources.关键词
牡蛎内脏多糖/抗氧化活性/四氯化碳/急性肝损伤Key words
polysaccharide from Crassostrea gigas internal organs/antioxidant activity/CCl4/acute hepatic injury分类
轻工纺织引用本文复制引用
王炫文,赵冠华,佟长青,李伟..牡蛎内脏多糖抗氧化活性及对四氯化碳所致小鼠急性肝损伤的影响作用[J].食品工业科技,2017,38(24):303-307,5.基金项目
海洋局公益性行业科研专项(201405017-03). （201405017-03）
