现代食品科技2018，Vol.34Issue(1)：1-4,103,5.DOI:10.13982/j.mfst.1673-9078.2018.1.001
双酚S暴露对秀丽隐杆线虫行为学及生长发育的影响
Effects of Bisphenol S Exposure on Behavior and Growth of Caenorhabditis elegans
摘要
Abstract
Bisphenol S (BPS) has been widely used as a substitute for bisphenol A (BPA) in various products (bottles,food cans,thermal paper,etc.),but there were few studies on toxicology of BPS.In this study,BPS was used as the research object,and Caenorhabditis elegans (C.elegans) was used as model organism to analyze its effect on the motor behavior and growth of C.elegans.The results showed that when the exposure concentration reached 1μM,the frequency of body movement was significantly decreased.And when the exposure concentration reached 10 μM,the thrashing frequency of the head was significantly decreased in the acute toxicity test.With the increase of concentration,BPS also affected the life span and the number of progeny of C.elegans,resulting in shortened life span and fewer brood size.When the concentration of BPS reached 100 μM,the life span decreased by 35.42％ and the brood size decreased by 30.47％ as compared with the control group;BPS exposure could lead to a significant increase of the reactive oxygen species (ROS) free radicals content in the C elegans,suggesting that high concentrations of BPS might cause oxidative damage to the C.elegans,and further affect the motor behavioral capacity,life span and the number of offspring.关键词
双酚S/秀丽隐杆线虫/内分泌干扰物/行为学/生长发育/食品包装材料/安全评价Key words
Bisphends (BPS)/C.elegans/endocrine disruptors/behavioristics/growth and development/food packaging materials/safety evaluation引用本文复制引用
周兴华,张晓伟,肖香,周越,赵延胜,祝莹,张家艳,董英..双酚S暴露对秀丽隐杆线虫行为学及生长发育的影响[J].现代食品科技,2018,34(1):1-4,103,5.基金项目
国家自然科学基金资助项目(31501569) （31501569）
江苏大学高级专业人才专项(13JDG037) （13JDG037）
