现代食品科技2018，Vol.34Issue(1)：5-12,8.DOI:10.13982/j.mfst.1673-9078.2018.1.002
四联活菌制剂Bornlisy对小鼠酒精性肝损伤的保护作用研究
Protective Effect of Bornlisy on Murine Alcoholic-induced Liver Injury and Mechanisms Exploring
摘要
Abstract
In order to investigate the protective effect of probiotics compound preparations Bornlisy (BO) on murine alcoholic-induced liver injury and explore the underlying mechanisms,acute and chronic alcoholic liver injuries models were establishedin mice by gavage with different concentrations of liquor.Compared with the model group,the survival rate of acute alcoholic liver injury mice with BO treatment was significantly improved (p＜0.05),while there was no such effect in BO supernatant treatment group.In chronic alcoholic liver injury model,BO could significantly reduce the increase of liver index and improve fatty pathological injuries and lipid accumulation (p＜0.05).Levels of serum ALT and TG decreased significantly (p＜0.05),and the activity of liver SOD and GSH-Px increased significantly by 43.30％(p＜0.05) and 281.44％ in BO treatment group (p＜0.01),respectively,while BO supernatant treatment group had no certain effects.Through investigating the fatty acid metabolic pathways,we found that BO treatment could inhibit the decrease of mRNA levels of PPARα,ACOX1 and L-FABP significantly (p＜0.05),while BO supematant treatment had no significant effects (p＞0.05).The detection results of SREBP-1c pathway showed that both BO and BO supernatant treatment had no significant effects on SREBP-1c and FAS mRNA expressions.Therefore,BO can protectmice from alcoholic induced liver injuries,which may be achieved by anti-oxidative stress and selectively enhancing PPARα pathway.关键词
益生菌复方制剂/酒精性肝损伤/脂代谢/过氧化物酶体增殖剂激活受体α/固醇调节元件结合蛋白Key words
probiotics compound preparations/alcoholic-induced liver injury/lipid metabolism/PPARα/SREBP-1c引用本文复制引用
童垣皓,蒙龙锡宇,赵亚蓉,沈苏南,赵树立,窦环..四联活菌制剂Bornlisy对小鼠酒精性肝损伤的保护作用研究[J].现代食品科技,2018,34(1):5-12,8.基金项目
国家自然科学基金项目(81402940) （81402940）
江苏省自然科学基金项目(BK20140615) （BK20140615）
南京大学本科生创新训练计划国家级项目(G201710284123) （G201710284123）
