食品工业科技2018，Vol.39Issue(3)：301-304,4.DOI:10.13386/j.issn1002-0306.2018.03.057
八月瓜提取物对四氯化碳诱导小鼠肝损伤的保护作用
Hepatoprotective effect of Fructus Akebiae extract on liver injury induced by carbon tetrachloride in mice
摘要
Abstract
To investigate the hepatoprotective effects of the different polarity fractions of extracts from the Fructus Akebiae on liver injury of CCl4-treated mice.Different polarities crude extracts of Fructus Akebiae were obtained by using petroleum ether,ethyl acetate,butanol,and water.The liver injury models of mice were prepared with the intragastric administration of 0.3％ CCl4.The effects of different polarity fractions of Fructus Akebiae extracts on serum ALT and AST levels,SOD activities and MDA level in liver homogenate,and a pathological examination for the mice liver tissues were performed.The results indicated that the butanol extract and water extract of fructus akebiae could obviously reduce the activities of ALT and AST in CCl4-treatedm ice,and increase the activities of SOD in hepatic tissue,and lower the content of MDA.The pathological section showed the butanol extract and water extract could improve the pathological changes of liver tissue.The results showed that butanol extract and water extract of Fructus Akebiae had noticeable protective effect against liver injury.关键词
八月瓜提取物/四氯化碳/肝损伤/保护作用Key words
Fructus Akebiae extract/carbon tetrachloride/liver injury/protective effects分类
轻工纺织引用本文复制引用
张亚平,周瑜,金洪光,廖亮,帅丽华..八月瓜提取物对四氯化碳诱导小鼠肝损伤的保护作用[J].食品工业科技,2018,39(3):301-304,4.基金项目
江西省自然科学基金(20161BAB204165) （20161BAB204165）
九江学院校级科研项目(2015LGYB36). （2015LGYB36）
