食品与机械2017，Vol.33Issue(12)：45-49,5.DOI:10.13652/j.issn.1003-5788.2017.12.009
蒲公英绿原酸固体分散体性能分析与比较
Analysis and comparison on solid ispersion performance of dandelion chlorogenic acid
摘要
Abstract
To use the solid dispersion method that could improve the dissolution rate of chlorogenic acid.With the factor experiment design,chlorogenic acid solid was mixed with PVPK30 and PEG4000 respectively,with the feed auxiliary ratio of 1︰2,1︰4,1︰6,1︰8.The finished product of solid dispersion prepared by four types of mixture ratio were compared in the vitro solubility,cumulative disso-lution and stability,and the optimal mixture ratio was analyzed by SEM.The experiment showed that chlorogenic acid solid dispersion could be prepared by mixture ratio of 1︰4,with PVPK30 as carrier. Compared with crude drugs,in vitro solubility and dissolution of chlorogenic acid solid dispersion increased obviously.With the SEM, chlorogenic acid existed in PVPK30 as the form of non-crystal,the surface with many small holes that could improve the dissolution and absorption.Chlorogenic acid-PVPK30 solid dispersion improves the properties of solubility and dissolution,better than those of raw medicine.关键词
绿原酸/固体分散体/溶解度/溶出度Key words
Chlorogenic acid/solid dispersion/solubility/dissolution引用本文复制引用
李妍,王杰,曹珂珂,汪张贵,王娣..蒲公英绿原酸固体分散体性能分析与比较[J].食品与机械,2017,33(12):45-49,5.基金项目
安徽省教育厅重点科研项目(编号:KJ2015A204) （编号:KJ2015A204）
蚌埠学院自然科学重点项目(编号:2017ZR06zd) （编号:2017ZR06zd）
