食品工业科技2018，Vol.39Issue(5)：110-112,118,4.DOI:10.13386/j.issn1002-0306.2018.05.021
联合使用羧甲基壳聚糖与阿霉素抗肿瘤效应
Effects on tumor cells by combination with carboxymethyl-chitosan and adriamycin
摘要
Abstract
The effect of anti-tumor combining carboxymethyl-chitosan(CM-CTS) with adriamycin (ADM) was studied.Colony forming test and trauma test were used to evaluate the effec ts of CM-CTS and ADM on cell proliferation and cell migration of Hela in vitro.Animal experiment was used to evaluate the anti-tumor activity of CM-CTS and ADM in vivo.The results showed that combining CM-CTS with ADM could inhibit clone forming rate of Hela by 72.65％,which was significantly higher than treating Hela with CM-CTS(31.47％)or ADM (44.09％)only(p ＜ 0.01).The migration ability of Hela could be inhibited when Hela was treated by CM-CTS and ADM together.And the inhibition rate was 84.48％,which was significantly higher than that of CTS (37.47％) or ADM (56.29％) (p ＜ 0.01).Animal experiment showed that the suppression rate of CM-CTS or ADM was 16.96％ or 27.68％ (p ＜ 0.01).While two-drug combination had a synergistic effect,which inhibited the tumor growth by 47.32％.Therefore,synergistic effect of CM-CTS and ADM could effectively inhibit cell proliferation and migration of Hela.关键词
羧甲基壳聚糖/阿霉素/癌细胞/增殖Key words
carboxymethyl-chitosan/adriamycin/cancer cell/proliferation分类
轻工纺织引用本文复制引用
李诗怡,杨靖亚,喻文娟,刘晓艳,马燕..联合使用羧甲基壳聚糖与阿霉素抗肿瘤效应[J].食品工业科技,2018,39(5):110-112,118,4.基金项目
上海市科委工程中心能力提升项目(16DZ2280300). （16DZ2280300）
