食品与机械2018，Vol.34Issue(2)：42-45,128,5.DOI:10.13652/j.issn.1003-5788.2018.02.009
氧载体对绿色产色链霉菌发酵生产阿维拉霉素的影响
Effects of oxygen vectors on microbial production of avilamycin
摘要
Abstract
In order to improve oxygen delivery efficiency and dissolved oxygen levels for the production of avilamycin in the fermentation broth,the effects were studied,including the various oxygen carriers on the synthesis of avilamycin and the growth of Streptomyces viri-dochromogenes.The results showed that Tween-80 was the most ef-fective vector to promote growth and the ability of Streptomyces viridochromogene to produce avilamycin.With the addition of 3 g/L tween at 8 h fermentation,the biomass reached 11.82 g/L and the avilamycin titer increased to 340 mg/L,which was 20.63% and 21.42% higher than the control group.Result show that the oxygen carrier of Tween-80 can increase the production of avilamycin by in-creasing the biomass and yield coefficient.关键词
绿色产色链霉菌/阿维拉霉素/氧载体/发酵Key words
Streptomyces viridochromogene/avilamycin/oxygen-vec-tor/fermentation引用本文复制引用
章梅,宋元达,刘青,王友玲,吴翰..氧载体对绿色产色链霉菌发酵生产阿维拉霉素的影响[J].食品与机械,2018,34(2):42-45,128,5.基金项目
国家自然科学基金(编号:31670064) （编号:31670064）
江苏凌云药业"链霉菌基因工程改造横向合作项目"(编号:2016-科技-90) （编号:2016-科技-90）
