食品工业科技2018，Vol.39Issue(8)：272-278,7.DOI:10.13386/j.issn1002-0306.2018.08.050
墨西哥黄唇鱼鱼肉胶原肽促进小鼠伤口愈合作用
Effect of Totoaba macdonaldi-meat collagen peptides on wound healing in mice
来梦婕 1陈玉峰 1张英 1楚秉泉1
作者信息
- 1. 浙江大学生物系统工程与食品科学学院,浙江省农产品加工技术研究重点实验室,浙江省食品加工技术与装备工程研究中心,浙江杭州310058
- 折叠
摘要
Abstract
Totoaba macdonaldi-meat collagen peptides (TMCP)with molecular weight of 837 Da obtained from Mexican farmed Totoaba used combinative enzyme to investigate its effects on wound healing in mice.40 healthy male ICR mice were underwent surgical full-thickness incision with a diameter of 8 mm and were divided into 4 groups,which were normal control group and 0.66,1.33,2.0 g/kg.bw TMCP groups.TMCP were orally administered by gavage to mice in TMCP group from post-operation,and the control mice were given vehicle only for 14 d.The healing of the wound were observed every 2 d.Necropsy was performed on postoperative 7 and 14 d.The wound tissues were excised for HE staining,Masson staining,hydroxyproline measurement and immunohistochemical analysis.According to results,TMCP-M and TMCP-H had highly significant positive effect on all indexes (p ＜ 0.01).TMCP-L could highly significantly increase the healing rate,collagen content,VEGF and bFGF expression on 14 d(p ＜ 0.01).TMCP groups could promote collagen producing and tissue remodeling.TMCP had potential to promote wound healing and could be used in high-quality oral healthy products,that would provide a theoretical basis for high -efficient utilization.关键词
墨西哥黄唇鱼/胶原肽/皮肤创伤/口服给药/伤口愈合Key words
Totoaba macdonaldi-meat/collagen peptides/excision wound/oral ingestion/wound healing分类
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来梦婕,陈玉峰,张英,楚秉泉..墨西哥黄唇鱼鱼肉胶原肽促进小鼠伤口愈合作用[J].食品工业科技,2018,39(8):272-278,7.
