食品与发酵工业2018，Vol.44Issue(4)：226-233,8.DOI:10.13995/j.cnki.11-1802/ts.014783
QuEChERS-超高效液相色谱-串联质谱法同时测定蜂蜜中21种磺胺类药物残留
Simultaneous determination of twenty-one sulfonamides residues in honey by QuEChERS ultra liquid chromatography-mass mass spectrometry
摘要
Abstract
The method for simultaneous determination of 21 sulfonamide residues in honey was developed by Ultra high performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS).Deuterium substituted standards were used as internal standards and added to the sample before extraction.The sample was dissolved by buffer solution (pH =4.00),extracted with 1％ formic acid in acetonitrile,purified by salting-out and cleaned up by NH2 adsorbent.The mass spectrometer was operated in the positive ion mode using multiple-reaction monitoring for qualitative and quantization.The detection limit of the method was 0.12-2.46 μg/kg.The correlation coeficient of linear calibration curve was over 0.99 within the range of sulfonamides concentration O.05-60 ng/mL.The average recoveries for 21 sulfonamide residues were 60.44％-107.80％.The method is simple、rapid、reliable、stable and sensitive.It's suitable for high throughout determination of 21 sulfonamide residues in honey.关键词
QuEChERS/液相色谱-串联质谱/磺胺类药物/蜂蜜残留Key words
QuEChERS/ultra liquid chromatography-mass mass/sulfonamide/honey residue引用本文复制引用
容裕棠,张宪臣,张朋杰,李蓉,黄伟蓉,陈丽斯..QuEChERS-超高效液相色谱-串联质谱法同时测定蜂蜜中21种磺胺类药物残留[J].食品与发酵工业,2018,44(4):226-233,8.基金项目
国家质检总局科技计划项目(2015IK052) （2015IK052）
广东省科技计划项目(2015A050502010) （2015A050502010）
广东检验检疫局科技计划项目(2017GDK24) （2017GDK24）
2017年中山市重大社会公益项目(2017B1029) （2017B1029）
