食品与机械2018，Vol.34Issue(1)：17-22,6.DOI:10.13652/j.issn.1003-5788.2018.01.004
蜂胶复方产品对心肌肥厚改善机制的转录组学研究
RNA-Seq analysis of improving mechanism for cardiac hypertrophy of a propolis product
摘要
Abstract
To study the improving mechanism of a propolis product on cardiac hypertrophy,spontaneously hypertensive rats (SHRs) were picked as animal models.After continuous infusion of this propolis product for 35 d,left ventricular index were calculated and RNA-Seq was performed.Differentially expressed genes (DEGs) were screened with the following GO enrichment analysis and KEGG metabolic pathway analysis.Totally 1 297 DEGs (91 DEGs were up-regulated and 1 206 DEGs were down-regulated) were selected.Results of KEGG metabolic pathways showed that 410 DEGs were enriched into 182 KEGG pathways,among which the top three DEGs enrich ment is closely related to insulin signal transduction pathways,namely PI3K-Akt signaling pathway,insulin signaling pathway and MAPK signal pathway.It was indicated that the effect of the propolis product on the myocardial hypertrophy of SHRs was improved and the main KEGG pathways were associated with insulin signal transduction.关键词
蜂产品/自发性高血压大鼠/心肌肥厚/RNA-Seq/胰岛素信号通路Key words
bee product/spontaneously hypertensive rat/cardiac hypertrophy/RNA-Seq/insulin signaling pathway引用本文复制引用
孙燕如,韩鸣凤,沈圳煌,吴珍红,缪晓青..蜂胶复方产品对心肌肥厚改善机制的转录组学研究[J].食品与机械,2018,34(1):17-22,6.基金项目
农业部蜂产业体系蜂产品保健功能岗位科学家专项基金(编号:CARS-45-KXJ19) （编号:CARS-45-KXJ19）
