中国食物与营养2018，Vol.24Issue(4)：62-65,4.
妊娠期高果糖膳食对子代胰岛素抵抗的影响
Effect of High Fructose Diet During Pregnancy on Insulin Resistance in Offspring
肖子义 1贺娟 2梁惠 1赵婷 2吴若男 1马爱国 1韩磊2
作者信息
- 1. 青岛大学公共卫生学院,山东青岛266021
- 2. 青岛大学附属医院,山东青岛266021
- 折叠
摘要
Abstract
[Objective] To study effects of high fructose diet in pregnancy on insulin resistance in offspring.[Method] We observed the effect of high fructose diet throughout pregnancy in pregnant rats.Rats were randomly divided into control group,normal does of fructose group,high does of fructose group,super high does of fructose and super high does of sucrose.Each group was given different doses of intervention substance by intragastric administration.The whole period lasted 21days.Delivery of rats fed with normal diet,measured body weight and fasting glucose.Fasting glucose and OGTT tests were measured on the eighth weekend.Second days after fasting for 12 hours,we killed rats,anesthetized,took blood,measured serum insulin levels,and calculated insulin resistance index.[Result] Continuous intervention in pregnant rats throughout pregnancy,the body weight of the high fructose group and the super high fructose group were significantly higher than that of the control group (P ＜0.05),fasting blood glucose of delivery of rat in the high dose fructose group was significantly higher than the control group (P ＜0.05).OGTT:in 30minutes,the blood glucose in the high dose fructose group,the super high dose fructose group and the super high dose sucrose group were significantly higher than that in the control group and the normal dose fructose group (P ＜0.05).In 120minutes,the blood glucose in the high dose fructose group,the ultra high dose fructose group and the ultra high dose sucrose group were significantly higher than that in the normal control group (P ＜ 0.05).The levels of serum insulin and insulin resistance in the high fructose group,the super high fructose group and the super high sucrose group were significantly higher than that in the control group and the normal dose fructose group (P ＜ 0.05).[Conclusion] High fructose diet during pregnancy can increase the risk of insulin resistance and glucose metabolism in offspring.关键词
果糖/子代/胰岛素抵抗/血糖Key words
fructose/fetal/IR/blood glucose引用本文复制引用
肖子义,贺娟,梁惠,赵婷,吴若男,马爱国,韩磊..妊娠期高果糖膳食对子代胰岛素抵抗的影响[J].中国食物与营养,2018,24(4):62-65,4.
