食品科学2018，Vol.39Issue(9)：140-144,5.DOI:10.7506/spkx1002-6630-201809022
鲍内脏多糖体内抗氧化及增强小鼠免疫活性
In Vivo Antioxidant Capacity and Immunoenhancing Activity in Mice of Polysaccharides from Abalone Viscera
摘要
Abstract
The objective of this work was to explore the in vivo antioxidant capacity of abalone viscera polysaccharides (AVP) and its immunoenhancing activity in mice. An animal model of ethanol-induced oxidative injury and normal mice were used for this experiment. The in vivo antioxidant capacity was evaluated by measuring superoxide dismutase (SOD) activity, and the contents of glutathione (GSH), malondialdehyde (MDA) and protein carbonyl content in liver. The immunoenhancing activity was determined with respect to immune orange indices, cell immunity, humoral immunity and nonspecific immunity. For this purpose, we measured immune organ indices, footpad swelling, hemolysin antibody level and phagocytic index (α). Results showed that AVP exerted good in vivo antioxidant capacity by significantly increasing SOD activity and GSH level (P < 0.05), and reducing the contents of MDA and protein carbonyl (P < 0.05) in the liver of mice with ethanol-induced oxidative injury. Furthermore, AVP enhanced immune function in normal mice by significantly increasing spleen and thymus indices, footpad swelling, serum hemolysin level (P < 0.01) and α value (P < 0.05). Additionally, our data demonstrated that both the antioxidant capacity and immunoenhancing activity of AVP were concentration dependent. This study can provide a theoretical basis for intensive processing and industrial development of abalone viscera.关键词
鲍内脏多糖/体内抗氧化/增强免疫Key words
abalone visceral polysaccharides/ in vivo antioxidant activity/ immunoenhancing activity分类
轻工纺织引用本文复制引用
魏好程,邵杰,何传波,李漫,熊何健..鲍内脏多糖体内抗氧化及增强小鼠免疫活性[J].食品科学,2018,39(9):140-144,5.基金项目
国家海洋局海洋公益性行业科研专项(201405016) （201405016）
福建省科技引导性项目(2016N0022) （2016N0022）
福建省教育厅项目(B15104) （B15104）
