食品科学2018，Vol.39Issue(11)：191-195,5.DOI:10.7506/spkx1002-6630-201811030
白桦脂酸与红枣总三萜酸对小鼠酒精肝损伤的保护作用
Protective Effects of Betulinic Acid and Total Triterpenic Acids from Red Jujubes on Alcoholic Liver Injury in Mice
摘要
Abstract
The protective effects of betulinic acid (BA) and total triterpenic acids from red jujube (JTTA) on alcoholic liver injury in mice were investigated. A mouse model of alcoholic liver injury was established by intragastrically treating mice with alcohol. Body weight, liver index and relevant biochemical indicators were determined. Histopathological changes in the liver were detected by staining liver sections with hematoxylin and eosin. The results showed that BA and JTTA could reduce liver index, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities and total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels in serum, increase high-density lipoprotein cholesterol (HDL-C) levels in serum and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activities, and decrease malondialdehyde (MDA) levels in liver tissue significantly (P ＜ 0.05). Furthermore, BA and JTTA could repair pathological liver injury. The results demonstrated that BA and JTTA could protect the liver from alcohol-induced injury.关键词
白桦脂酸/红枣/总三萜酸/酒精性肝损伤/保护作用Key words
betulinic acid/ red jujube/ total triterpenic acids/ alcoholic liver injury/ protective effect分类
轻工纺织引用本文复制引用
蔡天娇,王瑞珍,魏君慧,薛媛,雷宏杰,徐怀德..白桦脂酸与红枣总三萜酸对小鼠酒精肝损伤的保护作用[J].食品科学,2018,39(11):191-195,5.基金项目
陕西省难题攻关项目(2013KTZB02-03-04) （2013KTZB02-03-04）
