食品科学2018，Vol.39Issue(12)：119-125,7.DOI:10.7506/spkx1002-6630-201812019
莲原花青素低聚体在模拟生理环境下对非酶糖化末端产物的抑制作用
Inhibitory Effect of Oligomeric Procyanidins of Lotus Seedpod on Advanced Glycation End Products Formation in Simulated Physiological Environment
摘要
Abstract
The objective of this work was to explore the inhibitory effect of oligomeric procyanidins of lotus seedpod (LSOPC) on the formation of advanced glycation end products (AGEs) in a simulated physiological environment. The percentage inhibition of AGEs by LSOPC in the presence of metal ions, high glucose and high protein concentration was determined and the inhibitory effect of LSOPC complexes with epigallocatechin gallate (EGCG) on the formation of AGEs was evaluated. The results showed that the optimal incubation time to obtain the highest inhibitory effect of LSOPC was 35 d. Inhibitory effects on AGEs formation varied depending on the type and concentration of metal irons added. Cu2+and Fe2+had the highest promoting effects on AGEs formation and could work together with LSOPC. Five other metal irons had different inhibitory or promoting effects on AGEs formation but hardly influenced the effect of LSOPC. We also found that LSOPC had the lowest inhibitory effect at high concentrations of both BSA and glucose or at high concentrations of BSA. Additionally, LSOPC in combination with EGCG showed a potent synergistic inhibitory effect and the optimal effect was obtained at a ratio of 2:1.关键词
莲原花青素低聚体/非酶糖化末端产物/模拟生理环境/抑制作用Key words
oligomeric procyanidins of lotus seedpod (LSOPC)/advanced glycation end products (AGEs)/simulate physiological environment/inhibitory effect分类
轻工纺织引用本文复制引用
闵瑶瑶,周梦舟,柳志杰,冯年捷,吴茜..莲原花青素低聚体在模拟生理环境下对非酶糖化末端产物的抑制作用[J].食品科学,2018,39(12):119-125,7.基金项目
湖北省自然科学基金项目(4115/00051) （4115/00051）
湖北工业大学博士启动基金项目(4301/00047 （）
BSQD2017016) （）
国家自然科学基金青年科学基金项目(31601455) （31601455）
"十三五"国家重点研发计划重点专项(2016YFD0400701) （2016YFD0400701）
湖北省技术创新专项重大项目(2016ABA085) （2016ABA085）
