现代食品科技2018，Vol.34Issue(4)：6-10,5.DOI:10.13982/j.mfst.1673-9078.2018.04.002
野生猕猴桃与维生素C对大鼠酒精性肝脑损伤的预防性保护作用
Preventive Protective Effects of Wild Kiwifruit and Vitamin C on Alcoholic Liver and Brain Injury in Rats
摘要
Abstract
The preventive protective effects of wild kiwifruit and pure vitamin C on alcoholic liver and brain injury in rats were investigated in this study. 40 male SD rats were randomly divided into four groups: normal group, model group, vitamin C group and wild kiwifruit group. The normal group was given the same amount of normal saline, and other groups were given 56°Red Star Erguotou by gavage to establish the alcoholic liver and brain injury model (8 m L/kg for first week, and 10 m L/kg for the second week once a day). The normal group and the model group were given the common feed. The wild kiwifruit group was fed with 30％ concentration of wild kiwifruit, and the vitamin C group was given vitamin C-fortified feed (420 mg/kg). The liver function, liver lipid content and oxidative stress level were measured after two weeks, and pathological changes of liver and brain were observed by HE staining. Results showed that compared with the model group, wild kiwifruit and vitamin C could significantly reduce alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (TC), lipid peroxidation (LPO), malondialdehyde (MDA) in serum, and increase superoxide dismutase (SOD) in serum and brain homogenate (p＜0. 01). In addition, the decrease and increase indexes were even more significant in wild kiwifruit group (p＜0. 05). Consequently, wild kiwifruit and vitamin C had preventive protection effects on alcoholic liver and brain injury, and the former had the better effects.关键词
野生猕猴桃/维生素C/酒精性肝损伤/酒精性脑损伤/预防性保护作用Key words
wild kiwifruit/vitamin C/alcoholic liver injury/alcoholic brain injury/preventive protective effects引用本文复制引用
陈霞,张锐,胡锴,罗婷婷,郭文博,杨艳..野生猕猴桃与维生素C对大鼠酒精性肝脑损伤的预防性保护作用[J].现代食品科技,2018,34(4):6-10,5.基金项目
国家级大学生创新创业训练计划项目(201610632002) （201610632002）
西南医科大学-宜宾县人民政府合作项目基金(2014YDHZ-005) （2014YDHZ-005）
