现代食品科技2018，Vol.34Issue(7)：1-7,7.DOI:10.13982/j.mfst.1673-9078.2018.7.001
海带内生真菌Galactomyces geotrichum次生代谢产物改善小鼠的学习记忆能力
Improvement of Memory and Learning Ability of Mice by Secondary Metabolites of Galactomyces geotrichum
摘要
Abstract
This work reported that the ethyl acetate extract of secondary metabolites of endophytic fungus Galactomyces geotrichum could improve the memory and learning ability of mice. With D-galactose-induced the Alzheimer's disease (AD) mice as the model, the influence of different levels of dosages of the extract on the contents of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and malondialdehyde (MDA) in serum, liver and brain of the mice was investigated, using the Morris water maze test. The activities of choline acetyltransferase (Ch AT) and acetylcholinesterase (Ach E) in mice brain were also evaluated. The results showed that the escape latent period of the mice in each dose group was significantly shortened (p<0.05), and there was also noticable improvement in the spatial probe capability of the mice. Compared with the model group, the activities of SOD, GSH-Px and CAT in serum, liver and brain tissue of the low, middle and high dose groups were increased, while the MDA content decreased, the activity of Ach E decreased, as well as that of Ch AT increased in brain tissue. The findings indicated that the ethyl acetate extract of secondary metabolites could improve the memory and learning ability of the AD mice.关键词
内生真菌/学习记忆/抗氧化活性/白地霉Key words
endophytic fungi/ability of learning and memory/antioxidant activity/Galactomyces geotrichum引用本文复制引用
刘佳,田淑娟,仇宏伟,王凤舞..海带内生真菌Galactomyces geotrichum次生代谢产物改善小鼠的学习记忆能力[J].现代食品科技,2018,34(7):1-7,7.基金项目
山东省自然科学基金项目 (ZR2015BM016) （ZR2015BM016）
