现代食品科技2018，Vol.34Issue(7)：8-13,41,7.DOI:10.13982/j.mfst.1673-9078.2018.7.002
竹节参总皂苷改善高脂高糖饮食小鼠的神经炎症及可能的机制
Improvement of Neuroinflammation in Mice Induced by High-Fat-High-Fructose Diet by Saponins of Panax Japonicus and the Possible Underlying Mechanism
摘要
Abstract
The effects of saponins of Panax japonicus (SPJ) on the inflammatory response in the brain tissue of mice induced by high-fat-high-fructose diet (HFFD) were investigated. Balb/c mice were randomly divided into following groups: normal control group, model control group, SPJ-treated groups. Normal control mice were fed with standard diet, while model control group were fed with HFFD, and SPJ-treated groups were fed with HFFD combined with low-dose SPJ (100 mg/kg) and high dose SPJ (300 mg/kg) for 4 months. Compared with the normal control group, model control group exhibited increased cell apoptosis and microglia activation. Meanwhile, protein expression levels of inflammatory-related factors were significantly increased. Treatment mice with SPJ significantly improved the morphology and structure of brain tissue, inhibited neuronal cell apoptosis and microglia activation. In addition, SPJ significantly decreased the protein levels of inflammatory related factors such as i NOS, COX-2 and IL-1β, and inhibited the activation of NLRP3 inflammasome including NLRP3, ASC and Caspase-1. Thus, SPJ could improve the inflammatory response of brain tissue induced by HFFD, and its underlying mechanism might related to inhibition of the activation of NLRP3 inflammasome, leading to reduced expression levels of inflammatory factors.关键词
竹节参总皂苷/高脂高糖饮食/炎症反应/NLRP3炎症小体Key words
total saponis of Panax japonicus C.A.Mey./high-fat-high-fructose diet/inflammation/NLRP3 inflammasome引用本文复制引用
王东帆,王婷,王瑞,袁丁,张长城,刘朝奇,袁成福,周志勇,何毓敏,顿耀艳..竹节参总皂苷改善高脂高糖饮食小鼠的神经炎症及可能的机制[J].现代食品科技,2018,34(7):8-13,41,7.基金项目
三峡大学学位论文培优基金项目资助 （）
国家自然科学基金资助项目 (81374001) （81374001）
三峡大学重点实验室开放基金 (2016KXN05) （2016KXN05）
