李惠 1陈曦 2刘畅 2黄晶 2洪淼 1郝丽萍 1杨雪锋1
作者信息
- 1. 华中科技大学同济医学院公共卫生学院营养与食品卫生学系,食品营养与安全湖北省重点实验室,湖北武汉 430030
- 2. 武汉跃莱健康产业有限公司研究院,湖北武汉 430023
- 折叠
摘要
Abstract
The effects of Pu-erh tea extract, stigma maydis extract, oligofructose and their compound formula on glucose and lipid metabolism and insulin sensitivity in diabetic rats were investigated in this study. Eighty healthy adult male Sprague Dawley rats were randomly divided into 8 groups: The normal control group was given normal chow diet, the model control group, Pu'er tea group, oligofructose group, stigma maydis group and low, medium and high doses of compound formula groups were fed with high-fat diet. The treatment groups were given 6 test substances respectively by oral administration for 4 weeks, then, were intraperitoneally injected with Streptozocin to establish the model. And the test substances were continued until the end of the experiment. Glucose tolerance test was carried out at the beginning and the end of the experiment. Various indicators were measured after the experiment. Compared with the model control group, body weight, serum triglyceride, liver cholesterol, liver triglyceride, abdominal fat weight, organ coefficient and insulin resistance index in Pu'er tea group were reduced by 14.87％, 77.59％, 40.18％, 39.18％, 63.06％, 55.81％ and79.88％, respectively, but had no significant effect on serum glucose and glucose tolerance. In the oligofructose group, the abdominal fat weight, organ coefficient, and the insulin resistance index decreased by 30.99％, 29.46％ and 57.09％, respectively. In the stigma maydis group, only the liver triglyceride decreased by 36.06％.The compound formula significantly reduced body weight, body fat, serum lipids and hepatic lipid levels, and improved glucose and lipids dysmetabolism and insulin resistance effectively in STZ-induced diabetic rats.关键词
普洱茶提取物/低聚果糖/玉米须提取物/糖脂代谢/胰岛素抵抗Key words
Pu-Erh tea extract/oligofructose/stigma maydis extract/glucose and lipid metabolism/insulin resistance
