现代食品科技2018，Vol.34Issue(7)：21-27,7.DOI:10.13982/j.mfst.1673-9078.2018.7.004
甘草酸对酒精性肝损伤大鼠脏器的保护作用:18 α-与18 β-甘草酸配比的影响
Protection of Viscera in Rat with Alcohol-induced Liver Injures by Glycyrrhizic Acid: Influence of the ratio of 18α-, 18β-Glycyrrhizic Acid
摘要
Abstract
The objective of this paper was to investigate the effect of different proportions of 18α-and 18β-glycyrrhizic acid (Gly) on the morphology of organs in rats with alcoholic liver injury. Healthy male rats were randomly divided into ten groups, including normal control group, model group, positive control group (silymarin), 7 drug groups (18α-Gly and 18β-Gly group 10.83 mg/kg at ratios of 10:0, 8:2, 6:4, 5:5, 4:6, 2:8, 0:10). At the fourth week, important organs were collected and weighted, including liver, kidney and spleen, which were then stained by routine oil red O and hematoxylin-eosin. The histology of organs was observed by optical microscope. The results showed that 18α-Gly and 18β-Gly at the ratios of 2:8 significantly decreased organs indexes of respiratory and digestive system, obviously reduced muscle index and increased brain index, and meanwhile decreased cardiac index and spleen index. Additionally, 18α-Gly and 18β-Gly at the ratios of 4:6 and 2:8 reduced hepatocytes steatosis and lipid accumulation. 18α-Gly and 18β-Gly at the radio of 4:6 or less could decrease inflammation of the kidney, and meanwhile, alleviated injury to spleen demonstrated by the clear boundary of red and white pulp of spleen. Collectively, the optimal compatibility proportion of 18α-Gly and 18β-Gly on protecting organ injury induced by alcohol was 4:6 and 2:8.关键词
18α-甘草酸/18β-甘草酸/不同配比/酒精性肝损伤/脏器/组织病理Key words
18α-glycyrrhizic acid/18β-glycyrrhizic acid/different proportion/alcoholic liver disease/viscera/histology引用本文复制引用
孙晓可,杨飒,霍小位,王士中,孟祥波,赵燕燕..甘草酸对酒精性肝损伤大鼠脏器的保护作用:18 α-与18 β-甘草酸配比的影响[J].现代食品科技,2018,34(7):21-27,7.基金项目
河北省自然基金项目 (H2013201203) （H2013201203）
河北大学医学学科专项资金建设项目 (2014A1003) （2014A1003）
