中国食品学报2018，Vol.18Issue(8)：16-23,8.DOI:10.16429/j.1009-7848.2018.08.003
苦瓜粉缓解大鼠肥胖相关炎症的作用途径
The Mechanism of Bitter Melon Power Preventing Obesity-related Inflammation
摘要
Abstract
Objective: Study the effects of bitter melon power (BMP) on the prevention of obesity-related inflammation and its potential mechanism from the perspective of short fatty acids (SCFAs). Methods: Rats were fed with HFD and gavaged with water (4 mL/kg bw) and BMP (300 mg/kg bw) respectively for 14 weeks. Finally, we determinated the levels of blood glucose, serum lipid, inflammatory cytokines, endotoxin and SCFAs in intestinal tract of rats by Elisa and gas chromatography as to discover the potential mechanism. Results: BMP showed a higher anti-obesity activity with lower rate of increase of obese rats' body weights, significantly reversing glucose intolerance and hyperlipidemia, decreaseing the levels of inflammatory cytokines and endoxin. Morever, BMP markedly enhanced the production of acetic acid, propanoic acid, butyric acid in intestinal tract with the highest values 87.76 μmol/g, 5.34 μmol/g and 8.32 μmol/g respectively in the middle stage. Conclusion: BMP has benificial effects on the obesity-related inflammation, which is associated with the contents of SCFAs in intestinal.关键词
苦瓜粉/肥胖/炎症/短链脂肪酸Key words
bitter melon power/obesity/inflammation/short-chain fatty acids引用本文复制引用
白娟,祝莹,董英..苦瓜粉缓解大鼠肥胖相关炎症的作用途径[J].中国食品学报,2018,18(8):16-23,8.基金项目
国家自然科学基金项目 (31371760) （31371760）
江苏高校优势学科建设工程项目 （）
