中国食品学报2018，Vol.18Issue(8)：42-47,6.DOI:10.16429/j.1009-7848.2018.08.006
两种植物发酵液对氢化可的松致免疫抑制小鼠的免疫调节作用
Immunomodulatory Effect of Two Plant Fermentation Extracts (PFE) on Immunosuppressional Model Mice Induced by Hydrocortisone
摘要
Abstract
Object: Effect of two plant fermentation extracts (PFE) on immunosuppressional mice induced by hydrocortisone was investigated in this study. Method: Male BALB/c mice were randomly divided into 4 groups (including normal, model, Dr Leanne PFE and Yesdetox PFE) and orally administered the 2 PFEs respectively at a daily dosages of2.50 mL/kg BW (comparatively as 5 times of recommended human daily dosage). Saline was given to the normal group as the blank control. The treatments lasted for 30 days, and at the 23 rd day, all the animals except the normal group were given hydrocortisone subcutaneously for 7 days, while the normal group was given ethanol-saline solution. At the 31 st day, all the animals were executed and indexes, including serum immune factors, intestinal immune factors and immune organ indexes, were measured. Compared with the model group, both PFEs significantly increased the thymus index as well as the contents of serum IL-6, TNF-α, IFN-γ. No significant differences were observed in the spleen index, serum IgG contents and Complement 3 contents. The results indicate that the PFEs had no obvious impact on cellular immunity, but enhanced the intestinal immune barrier, and significantly promoted serum IL-6, TNF-α, IFN-γlevels.关键词
植物发酵液/氢化可的松/肠道免疫/免疫抑制/细胞免疫Key words
plant fermentation extracts/hydrocortisone/intestinal immune/immunosuppression/cellular immunity引用本文复制引用
姜城子,刘春花,潘永龙,吴彬彬,王彦博,梁岩..两种植物发酵液对氢化可的松致免疫抑制小鼠的免疫调节作用[J].中国食品学报,2018,18(8):42-47,6.基金项目
深圳市科技计划项目 (CXZZ20150529144041624, CXZZ20150422152108120) （CXZZ20150529144041624, CXZZ20150422152108120）
