中国食品学报2018，Vol.18Issue(8)：48-54,7.DOI:10.16429/j.1009-7848.2018.08.007
对虾中隐蔽态T-2毒素残留对雄性小鼠生长发育的影响及其遗传毒性效应
Effect of Masked T-2 Toxin in Litopenaeus vannamei on Growth and Development and Cytogenetic Toxicity of Male Mice
摘要
Abstract
Proven the toxic effect of masked T-2 toxin in Litopenaeus vannamei on growth and development and genetic of male mice. Mice, with head and muscle homogenates of the shrimps which were conducted the experiment of20 d accumulation toxicity with Does-periodic-increased methods through tube feeding for 7 d. Then recording the organ index, spermatozoa deformity and micronucleus of marrow cell were measured. Analysis of the toxic effects of T-2 and the hidden residues in the shrimp on mice. The results showed that low doses T-2 infected shrimp has no effect on mice. However, high dose T-2 infected shrimp caused decreasing of organ index. Sperm deformity rate and micronucleus rate were significantly higher than that of the control group (P＜0.05); With the increase of the exposure dose, the abnormal rate of sperm and the rate of micronucleus increased. Research shows T-2 in feed could transformed into masked T-2 toxins (m T-2 s) by shrimp after ingesting, T-2 was exposed to a certain genetic toxicity, and the contents of the masked T-2 in the head were higher than that in the muscle; which was positively correlated with the exposure dose.关键词
T-2毒素/隐蔽态/精子畸形率/微核率Key words
T-2 toxin/masked/sperm deformity rate/micronucleus rate引用本文复制引用
王小博,邱妹,王雅玲,孙力军,徐德峰,刘颖,叶日英,励建荣..对虾中隐蔽态T-2毒素残留对雄性小鼠生长发育的影响及其遗传毒性效应[J].中国食品学报,2018,18(8):48-54,7.基金项目
国家自然科学基金面上项目 (31171634, 31371777) （31171634, 31371777）
广东省渔业局项目 (粤财农[2015]115号) （粤财农[2015]115号）
广东省科技计划项目 (2014B020205006) （2014B020205006）
佛山市科技创新平台 (食品中有害物质快速检测技术科技创新研究与应用平台) 项目 (2015AG10023) （食品中有害物质快速检测技术科技创新研究与应用平台）
