现代食品科技2019，Vol.35Issue(9)：30-37,8.DOI:10.13982/j.mfst.1673-9078.2019.9.003
白鬼笔蘑菇菌丝体多糖:免疫调节和伤口愈合特性
Polysaccharides of Mushroom Phallus impudicus Mycelium: Immunomodulating and Wound Healing Properties
BUKO Vyacheslav 1BAKUNOVICH Alexey 2ASTROWSKI Aliaksandr 1MOROZ Valentina 1PUCHKOVA Tatyana 1KASTSIANEVICH Aliaksandar 3TOMULEWICZ Mikolaj3
作者信息
- 1. 国家科学院生化药学部,生物活性物质生化研究所,格罗德诺230030,白俄罗斯
- 2. 医科大学生物技术系,比亚韦斯托克15-825,波兰
- 3. 国家科学院微生物研究所,明斯克220141,白俄罗斯
- 折叠
摘要
Abstract
Mushroom Phallus impudicus is traditionally used in Asia and Northern Europe as a remedy of folk medicine.This review summarizes our own results on the artificial cultivation of the P.impudicus mycelium and some data on the study of the biological activity of polysaccharides isolated from this mycelium.The cultural-morphological and physiological-biochemical properties of the mycelium of the new fungal strain of P.impudicus were studied.The optimization of the nutrient medium composition and cultural conditions enabled to increase the biomass yield by 1.3-fold,and the contents of polysaccharides by 1.5 to 1.7-fold.The polysaocharides isolated from this mycelium possessed immunomodulating properties in vitro as well as in vivo in experimental rats with streptozotocin-induced diabetes.The ointment containing 10％ P.impudicus polysaccharides enhanced cutaneous wound healing in experimental rats,accelerating epithelialization,contraction and growth of granulation tissue as compared to the ointment base.Taken together,polysaccharides ofP.impudicus mycelium are promising raw material for the development of functional food as well as new therapeutic and prophylactic drugs.关键词
多糖/菌丝体/白鬼笔/免疫调节/伤口愈合Key words
polysaccharides/mycelium/P.impudicus/immunomodulation/wound healing引用本文复制引用
BUKO Vyacheslav,BAKUNOVICH Alexey,ASTROWSKI Aliaksandr,MOROZ Valentina,PUCHKOVA Tatyana,KASTSIANEVICH Aliaksandar,TOMULEWICZ Mikolaj..白鬼笔蘑菇菌丝体多糖:免疫调节和伤口愈合特性[J].现代食品科技,2019,35(9):30-37,8.
